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Malaysian team in Cambridge study

Malaysian team in Cambridge study
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DID you know that there are more than three billion alphabets in our genomes and just a single change in some genes like BRCA1 could put you at a higher risk of breast cancer?

But which of the 22,000 genes in a human genome are linked to cancer risk, who has these genetic changes and what should you do if you have them?

The University of Cambridge just released the world’s largest study on genes that cause an increased risk to breast cancer, with a significant part of the Asian research led by researchers at Cancer Research Malaysia (CRM), University Malaya, Subang Jaya Medical Centre and seven hospitals in Singapore.

“It is a huge milestone for cancer research worldwide and in Asia. There are over 113,000 participants from different countries, including a substantial number of Asian women, made possible because of our collaboration with Malaysian and Singaporean hospitals,” said Prof Datin Paduka Dr Teo Soo Hwang, Chief Scientific Officer at CRM, who co-led the study.

The sheer sample size of the study provides more accurate estimates for patients to understand their breast cancer risk, as well as suitable prevention options for them and their family.

“Previously, genetic tests for cancers and other diseases were offered to patients sometimes without any genetic counselling or without a complete understanding of what recommendations to take forward in terms of prevention and screening.

“Our study is highly important as it analysed the 34 genes commonly found in gene panel tests, narrowing it down to just 12 genes associated with breast cancer risk.

“We also discovered that Asians are just as likely as Caucasians to have these faulty genes. But we have a significantly lower 45 – 65 per cent lifetime risk of developing breast cancer, compared to Caucasians at 65 – 87 per cent.”

The study called BRIDGES, which stands for Breast Cancer Risk after Diagnostic Gene Sequencing, was published in the prestigious New England Journal of Medicine. Its findings will inform doctors, clinicians and even companies that offer genetic tests, on the right set of genes associated with breast cancer risk.

For Asian women who have a family history of breast or ovarian cancer, like Angelina Jolie, knowing their lifetime risk is lower and could mean making different decisions about prevention in consultation with a specialist.

The Malaysian component of the study is critical for lifesaving early detection, as there currently is not enough cancer research being done on Asian genes. — The Health

Tags: breast cancerCancer Research Malaysiagene studyLocal NewsThe Health ApriltheHealthUniversity of Cambridge
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