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This ring may just help protect women against HIV

This ring may just help protect women against HIV
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Learn how a new tool will help give this group greater power to prevent HIV on a monthly basis.

BY AMELIA HARNISH

In 2020, women and girls accounted for 50 per cent of new HIV infections worldwide. But across Africa, this group faces disproportionately higher rates from the AIDS-causing virus.

One out of every five new HIV infections in sub-Saharan Africa occurs among adolescent girls and young women, despite this group representing just 10 per cent of the population. In some African countries, 80 per cent of new adolescent HIV infections are among girls.

This World AIDS Day, there’s at least one sign of hope on the horizon for changing those numbers: a novel long-acting HIV prevention product called the dapivirine ring.

We need to have options available that allow women to best protect themselves. The dapivirine vaginal ring is something they can control.

Developed by the non-profit International Partnership for Microbicides (IPM), the ring is designed to release dapivirine—an antiretroviral (ARV) drug that helps prevent HIV from replicating inside cells—into the vagina.

IPM received the rights to develop dapivirine as a vaginal microbicide through a worldwide license from the Janssen Pharmaceutical Companies of Johnson & Johnson and Johnson & Johnson Global Public Health, which is also partnering closely with IPM to plan for the ring’s introduction to the world. This licence is designed to ensure that women in low-resource settings have affordable access to any dapivirine-based vaginal HIV prevention method.

“We need to have options available that allow women to best protect themselves,” says Zeda Rosenberg, ScD, IPM’s founder and CEO. “The dapivirine vaginal ring is something they can control”—putting the power to prevent HIV in their hands.

Why this innovation is so novel—and necessary

There are already daily ARV pills on the market that help prevent HIV, and a potential preventive injectable therapy is currently under review by the US Food
and Drug Administration. But “the ring fills a gap in options,” Rosenberg says, especially for women in African countries who continue to face an alarmingly high HIV risk and may have less sexual autonomy than women in other parts of the world.

For one thing, the ring is discreet. HIV prevention pills, Rosenberg explains, can be stigmatised in these countries because they can be misconstrued as HIV treatment. The ring also offers an alternative for women who are unable to take a pill every day or who simply don’t want to take a drug that works systemically—that is, throughout the body—because of the potential for greater side effects, she adds.

Here’s an inside look at how it works:

  1. The dapivirine ring is made of a flexible silicone matrix that’s comfortable to insert and generally isn’t felt once in place. It was modeled after a vaginal hormone replacement therapy ring called femRing, which releases estrogen to relieve menopause symptoms. Unlike some vaginal contraceptive rings, the dapivirine ring does not require refrigeration to store and has a five-year shelf life.
  2. The ring slowly releases a steady dose of dapivirine for 28 days. “Women insert it for one month at a time, then remove it and replace it with a new ring,” Rosenberg explains. A version of the ring that can be left in place for three months is currently in clinical trials.
  3. “Because the ring releases dapivirine locally into the vaginal tissue, relatively low amounts of the drug are absorbed into the blood system,” Rosenberg says. The benefits of this method of administration? Low potential for side effects, compared to other modes of drug administration.

Already approved for use in Zimbabwe, the dapivirine ring—which has already received a positive scientific opinion from the European Medicines Agency and a recommendation from the World Health Organisation—is expected to roll out throughout 2022 in some countries in Eastern and Southern Africa, where the need for new HIV prevention tools for women is greatest. — The Health

This article appeared recently on the website of Johnson & Johnson

Tags: AIDSHIVHIV PreventionInnovationPreventionThe Health 2022The Health Jan/FebtheHealth
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